We comply with the HONcode standard for trustworthy health information - If Tofranil (imipramine tablets) is stopped, your doctor will tell you when to start taking Tofranil (imipramine tablets) again after your surgery or procedure. Barbiturates (Fiorinal, Fioricet) Lorazepam (Ativan) Oxazepam (Serax) Anti-Mood Swings. In a pooled analysis of serum levels from published studies and 4 unpublished cases, the authors found that 15 mothers taking an average daily dosage of 83 mg (range 25 to 200 mg) had an average breastmilk sertraline level of 45 mcg/L (range 7 to 207 mcg/L). The best thing to do is to discuss your options carefully with a doctor, including your baby's pediatrician, and of course, your partner. Anticonvulsant (Depakote, Dilantin, Tegretol) Potentially Hazardous While Breastfeeding. Although some studies differ, most document maternal antenatal depression as causing slightly shorter gestational length and lower birth weight in newborns. Sertraline (Zoloft) Trazodone; Tricyclic antidepressants (Elavil, Pamelor,Tofranil) Anti-Anxiety/ Tension; Sedative. Once you discontinue medications, you can ask your doctor if you can restart breastfeeding. Because of the low levels of sertraline in breastmilk, amounts ingested by the infant are small and is usually not detected in the serum of the infant, although the weakly active metabolite norsertraline (desmethylsertraline) is often detectable in low levels in infant serum. Side effects requiring immediate medical attention. Mother-baby bonding is usually poor and they usually have less attachment. Anti-Depression. Pregnancy. Developmental delays also occur. Animal models have revealed evidence of embryotoxicity, reduced litter size, slightly increased stillborn rate, and decreased mean birth rate. You have to consider the benefits and risks of treating symptoms of depression while exposing a baby to the same medication, versus leaving your illness untreated, and versus not breastfeeding at all. Maternal Levels. Many new mothers are happy and excited about their newborn babies. There was a decrease in the milk supply in six patients who were on sertraline. Milk levels of imipramine and its metabolite are low and have not been detected in the serum of breastfed infants. Hale's Breastfeeding Safety Ratings: Part 2 - Antidepressants. Instead, they experience postnatal depression, a natural, yet very challenging feeling, especially to lactating women. Studies show that babies with depressed mothers who go untreated tend to have poor brain development. ... Tofranil (imipramine)." Some of the things to consider will probably include the severity of your depression, the baby's age, and your emotional need to nurse.Here is a summary of what treatments are safe and potentially unsafe. There is increasing evidence that antenatal and postnatal anxiety and depression potentially have enduring effects on offspring. A study was done to test how Zoloft and milk supply works. Available for Android and iOS devices. Imipramine use during breastfeeding would usually not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. If you're not sure, just stop breastfeeding but continue to pump out breast milk with a glass or plastic pump without giving the milk to your baby. Epidemiological studies have suggested an increased risk of congenital abnormalities in pregnancy and the use of antidepressants in pregnancy may be associated with an increase in pre-term delivery. It is therefore advisable to take a safe medication than to go untreated while taking care of a baby. However, some women feel overwhelmed soon after they have their babies, and the bliss of being a new mother seems not to last too long. This will ensure that your milk flow does not diminish, just in case you decide to breastfeed again.