Two additional patients, who did not wish to take corticosteroids, received hydroxychloroquine.

No evidence of optic neuritis, papilledema, or retinal damage was observed.

The patient became asymptomatic.  TBaughman
 et al.

In August 1983, computed tomography showed reduction in size of the pituitary mass.

I now use hydroxychloroquine sulfate exclusively in doses of 200 mg twice a day.  OHughs Lung function studies showed a vital capacity of 57%. 24 The dose is 200 to 400 mg/d. The diagnosis of sarcoidosis was based on the presence of noncaseating granulomas in the brain in 3 patients, in the lung in 5, in the lymph nodes in 2, in the nasal mucosa in 1, and in the skin in 1 patient. There was no response to either chloroquine or azathioprine.

 J Antimalarial medications in dermatology: a review. In the patients in whom corticosteroids are clearly contraindicated, chloroquine and hydroxychloroquine can play an important role. He was given prednisone, 60 mg daily, with instructions to continue treatment for 6 months.  GGilbert HCl). Muscle strength was normal in the shoulders, upper arms, and wrist extensors. He remained obese and depressed.  AMOuda

 Feds. The significance of the minimal stalling for median conduction was unclear. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ.  EBoederick The patient's condition stabilized initially, but the disease slowly progressed despite hydroxychloroquine therapy for 2 years. Fifth International Conference on Sarcoidosis and Other Granulomatous Disorders, Prague.

Although desirable, it is not always advisable or possible to perform a brain biopsy or obtain a neural specimen.

 H Outcome in sarcoidosis: the relationship of relapse to corticosteroid therapy. There was no weakness in the lower extremities. There was no evidence of radiculopathy.Treatment was restarted with prednisone, 60 mg daily.  MSharma Serum ACE level was normal.

Three months later, left facial palsy appeared. Along with the progressive weakness, wasting of the right hand and forearm muscles became prominent. Results of a nerve conduction study and electromyography were consistent with diffuse axonal neuropathy, predominantly motor, with some mild demyelinating features and relative preservation of the sensory potentials.The patient was given prednisone, 60 mg/d, which he took for 3 months. From the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, Los Angeles. All patients who received chloroquine or hydroxychloroquine had thorough eye evaluation, including a slit-lamp examination, at 3-month intervals by an ophthalmologist experienced in managing ocular sarcoidosis. She will continue to need treatment for a long period.In 1983, a 33-year-old man of Dutch ancestry developed acute iritis, fever, erythema nodosum, and joint pains. A transbronchial lung biopsy showed noncaseating granulomas.  NPerrin-Fayolle  TMan An MR image of the brain showed diffuse leptomeningeal enhancement in the frontal lobes, interhemispheric fissure, and right temporal and occipital lobes (Left, Gadolinum-enhanced magnetic resonance image (axial view) of the brain showing multiple areas of diffuse leptomeningeal enhancement in the temporal and occipital lobes.  RA The present status of treatment of pulmonary sarcoidosis: a house divided.
Zic  BSewell  GMagno Hydroxyurea fights cancer by preventing the growth of cancer cells, which eventually results in their destruction.  et al. The exact mechanism by which hydroxyurea works to treat cancer is not understood.

Subsequently, he received methotrexate, 20 mg orally, once a week for 3 months.  A Chloroquine therapy in 43 patients with intrathoracic and cutaneous sarcoidosis.