We opted to study the influence of the azalide antibiotic azithromycin on the duration of Q-Tc interval as data on this subject are limited. GnRH: Gonadotropin-releasing hormone agonists and antagonists; AIDS: acquired immunodeficiency syndrome; HIV: human immunodeficiency virus; SD: standard deviation; OR: odds ratio; CI: confidence interval; QTc:Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World PracticeDepartment of Biomedical Informatics, Ajou University School of Medicine, Suwon, Gyeonggi-do, Republic of KoreaDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Gyeonggi-do, Republic of KoreaDepartment of Cardiology, Ajou University School of Medicine, Suwon, Republic of Korea The types of medications and comorbidities are shown in Tables We calculated the distribution of the patient characteristics, laboratory test results, comorbidity, and medication use for the QT prolongation cases and controls from 1995 to 2015. QT prolongation was observed in 402 out of 1,305 individuals who were prescribed azithromycin and underwent ECG within 7 days (Table Therefore, it might be helpful to conduct ECG monitoring during azithromycin use, especially in elderly patients, to prevent QT prolongation-related critical events. 2020 Jun;26(6):808-809. doi: 10.1038/s41591-020-0888-2. O 02. This drug was associated with 2 cases of torsades de pointes reported to the US FDA between 1996 and 2001.Tachycardia has also been reported during postmarketing experience. Fostini R, Girelli M, Dalle VP, Benedetti M, Recchia G "Safety profile of ofloxacin in elderly patients." It may occur as an adverse effect of various pharmacological agents including macrolides. We analyse regional dynamics of unemployment rates and try to evaluate the impact of Active Labour Market Policies (ALMPs) in observed trends. Tack KJ, Smith JA "The safety profile of ofloxacin." Amiodarone-induced QTc prolongation, even when marked, does not predict recurrent torsade de pointes. In a subgroup analysis, the risk was not increased by azithromycin (OR=0.98 [0.56-1.72]) at ages below 29 years. The patients were previously healthy and were not receiving any other medication. —Clinical and electrocardiographic descriptors were extracted for analysis. Traeger SM, Bonfiglio MF, Wilson JA, Martin BR, Nackes NA "Seizures associated with ofloxacin therapy." Myasthenia gravis — macrolides may aggravate weakness symptoms. 1993;270:2590-2597)The safety and efficacy of long-term amiodarone therapy were examined in 12 patients who had previously developed torsade de pointes as a complication of previous antiarrhythmic therapy. A total of 332 patients were included in the analysis following application of prospectively defined criteria (eg, corrected QT [QTc] interval of 0.45 second or greater while receiving drug).Data Extraction. Cerner Multum, Inc. "UK Summary of Product Characteristics." In 1 case, a 49-year-old female developed diffuse numbness, "pins and needles" sensation, burning pain, Disturbances of taste, smell, hearing, and equilibrium were usually reversible after the drug was stopped.Severe liver injury (including cases of acute liver failure [sometimes fatal]) has been reported, primarily in patients with underlying liver disorders.-Common (1% to 10%): Injection site reactions (including phlebitis, swelling, Tendinitis and tendon rupture have also been reported during postmarketing experience. Compared to a drug-free control period, QTc was significantly prolonged (P less than 0.05) at the time of torsade de pointes, after amiodarone loading, and after 3 months of amiodarone therapy. In addition, 5 of 6 patients with a history of sustained ventricular tachycardia remained free from arrhythmic recurrence despite persistence of inducible ventricular tachycardia during programmed stimulation studies done before discharge. We conclude that amiodarone can often be used safely and effectively in patients who have previously had an episode of drug-mediated torsade de pointes. On the basis of a case report, this consideration is being discussed and put into perspective. The FDA is currently investigating Zithromax to see if further action can be taken against it. These observations also suggest that the propensity for a drug to produce this arrhythmia is dependent on other electrophysiologic effects in addition to its ability to simply lengthen repolarization.Amiodarone has been shown to affect cell membrane physicochemical properties, and it may produce a state of cellular hypothyroidism.