Therapy with these agents should be administered cautiously in patients with prior history of heart conditions.
We comply with the HONcode standard for trustworthy health information - Select one or more newsletters to continue. It is best to read this information with our general information about chemotherapy and targeted therapies. Patients who have received prior anthracyclines, those who received anthracycline after stopping therapy with agents that block HER2 activity, or patients who received prior radiotherapy to the chest area may be at higher risk of decreased LVEF. Pertuzumab (Perjeta ®) and trastuzumab are only used to treat breast cancers that have too much of a protein (receptor) called HER2 on the surface of their cells.This is called HER2-positive breast cancer. What does PERJETA treat?
And that kind of leads into my next question. Herceptin binds selectively to the HER2 protein, thereby reducing cancer cell growth and proliferation.
Decreases in left ventricular ejection fraction (LVEF) have been reported with agents that block HER2 activity. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
It is used to treat breast cancer that has spread to other areas, or come back in the same area. PERJETA ® (pertuzumab) is a prescription medicine approved for use in combination with Herceptin ® (trastuzumab) and chemotherapy for:.
So, I know that there are treatments, Herceptin and Perjeta, specifically for HER2-positive breast cancer. Pertuzumab, trastuzumab and docetaxel is a combination treatment.
Marleen Meyers: Yes. Still, women in the Perjeta treatment group were slightly more likely to have heart problems: 0.7% of women in the Perjeta treatment group had heart failure 0.4% of women in the standard treatment group had heart failure Discontinue treatment with agents that block HER2 activity as appropriate, and for a confirmed clinically significant decrease in left ventricular function, or if the LVEF has not improved or has declined further, unless the benefits for the individual patient outweigh the risks.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Discontinue treatment with agents that block HER2 activity as appropriate, and for a confirmed clinically significant decrease in left ventricular function, or if the LVEF has not improved or has declined further, unless the benefits for the individual patient outweigh the risks.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. So, it sounds like those treatments have perhaps, as you said, not made it any less aggressive, but made it perhaps more treatable. Both Perjeta and Herceptin can cause heart problems, but few women in each treatment group experienced those side effects. Available for Android and iOS devices. Patients who have received prior anthracyclines, those who received anthracycline after stopping therapy with agents that block HER2 activity, or patients who received prior radiotherapy to the chest area may be at higher risk of decreased LVEF. These include heart problems, fluid … Decreases in left ventricular ejection fraction (LVEF) have been reported with agents that block HER2 activity. Evaluate cardiac function before, during and upon completion of treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. We comply with the HONcode standard for trustworthy health information - There are a few foods and spices that have been shown to amplify the effects of Herceptin, thereby increasing its effectiveness. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
Evaluate cardiac function before, during and upon completion of treatment.
If you have HER2-positive early breast cancer that has spread to the lymph nodes or has a higher risk of coming back, you may have these drugs along with chemotherapy.
There are no known interactions between Herceptin and alcohol. Therapy with these agents should be administered cautiously in patients with prior history of heart conditions.