(Or, injectable BenadrylSymptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Protect from light.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Potentiation of Given the likelihood that some patients exposed
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Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely.
Warn patients to report the sudden appearance of sore throat or other signs of infection. Treatment with anti-parkinsonian agents,
the tongue may be an early sign of the syndrome and if the medication is
have been reported, usually with overdosage.Chromosomal aberrations in spermatocytes and abnormal
).Do not use in children under 2 years of age or under 20
These adverse events include hypotension, anticholinergic effects (such as
Sometimes these may be accompanied by involuntary movements of extremities.
The use of prochlorperazine and other potential hepatotoxins should be avoided in children and adolescents whose signs and symptoms suggest Reye’s syndrome.Children with acute illnesses (e.g., chicken-pox, CNS infections, measles, gastroenteritis) or dehydration seem to be much more susceptible to neuromuscular reactions, particularly dystonias, than are adults.
long-term course of the syndrome is unknown. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus.It is important to determine other medications taken by the patient since multiple-dose therapy is common in overdosage situations.
may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness.To Report SUSPECTED ADVERSE REACTIONS, contact Perrigo at
The decision to inform patients and/or their
with the lowest recommended dosage.Manufactured for PBM Pharmaceuticals, Inc., Charlottesville,
Reassurance and sedation are important. However, the syndrome can develop, although much less commonly,
Tell parents not to exceed prescribed dosage, since the possibility of adverse reactions increases as dosage rises.Occasionally the patient may react to the drug with signs of restlessness and excitement; if this occurs, do not administer additional doses.
where the clinical presentation includes both serious medical illness (e.g., If a patient requires antipsychotic drug treatment after
Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that, 1) is known to respond to antipsychotic drugs, and, 2) for whom alternative, equally effective, but potentially less harmful treatments are If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered.
CompazineThe Compazine brand name has been discontinued in the U.S. Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful.Symptoms may include: mask-like facies; drooling; tremors; pillrolling motion; cogwheel rigidity; and shuffling gait. symptoms following delivery.
symptoms or signs occur. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.)
so serious and There have been reported instances of prolonged jaundice,
While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. Patients with severe neutropenia (absolute neutrophil count < 1000/mmClinical studies of prochlorperazine did not include sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects.
If tests indicate an abnormality, stop treatment.
The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. physical dependence, sudden discontinuance in long-term psychiatric patients
However, it has been reported that phenothiazines may interfere with the metabolism of DilantinThe presence of phenothiazines may produce false-positive phenylketonuria (PKU) test results.Given the likelihood that some patients exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk.