Continue typing to refine. There is very little inter-subject variability in plasma levels. Le sotalol possède par ailleurs des propriétés antiarythmiques. Despite its widespread use, little information is available regarding dosing protocols during this period.
Patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take this medicine.Class IA antiarrhythmic drugs, such as disopyramide, quinidine and procainamide and other antiarrhythmics such as amiodarone and bepridil are not recommended as concomitant therapy with sotalol hydrochloride, because of their potential to prolong refractoriness (see section 4.4). Sotalol's ability to suppress ventricular ectopy is similar to that of class I agents and better than that of standard beta-blockers.
Although there are no adequate and well-controlled studies in pregnant women, sotalol hydrochloride has been shown to cross the placenta and is found in amniotic fluid.
No dosage adjustment is required in hepatically impaired patients.Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.Sotalol hydrochloride tablets are contraindicated in the following:- Second and third degree AV heart block unless a functioning pacemaker is present.- Raynaud's phenomenon and severe peripheral circulatory disturbances.- History of chronic obstructive airway disease or bronchial asthma.- Hypersensitivity to any of the components of the formulation.- Renal failure (creatinine clearance < 10 ml/min). This information is intended for use by health professionalsEach tablet contains 13.37mg of lactose (as lactose monohydrate).White, round, biconvex tablets of diameter 5.4mm–5.6mm and height of 2.8mm-3.0mm, marked “SOT” on one side. Si vous avez l'impression que l'effet de SOTALOL BIOGARAN 80 mg, comprimé sécable est trop fort ou trop faible, consultez votre médecin ou votre pharmacien. Drugs that have been associated with an increased risk of ventricular arrhythmias, particularly torsades de pointes include erythromycin IV, halofantrine, pentamidine and fluoroquinolones. Sotalol, a Vaughan-Williams Class III antiarrhythmic medication, is used to manage atrial arrhythmias. Beta- blockers should be avoided in combination with cardiodepressant calcium channel blockers such as verapamil and diltiazem because of the additive effects on atrioventricular conduction and ventricular function. His QT prolongation and hypotension responded to IV calcium and glucagon treatment. tachycardia.Beta-blockade may mask certain clinical signs of hyperthyroidism (e.g. She took oseltamivir 75 mg bd for presumed influenza and after 4 days developed ventricular fibrillation. Elle est augmentée progressivement jusqu'à la dose de 160 à 320 mg par jour, répartie en 2 prises.Il est normal que le rythme cardiaque ralentisse sous l'effet du traitement ; néanmoins, en cas de fatigue anormale et de pouls inférieur à 50 battements par minute, consultez votre médecin.Vous avez ressenti un effet indésirable susceptible d’être dû à ce médicament, vous pouvez le
After 3 days she had only mild prolongation of the QT interval, but 2 weeks later, a day after the death of her husband, she had severe QT interval prolongation in the absence of signs or symptoms of cardiac dysfunction.A 57-year-old man with a 3-year history of symptomatic paroxysmal atrial fibrillation reverted to sinus rhythm with no evidence of recurrence after taking sotalol 120 mg bd.
Sotalol was 1 of 2 drugs selected for comparison with implantable defibrillators in the recent National Institutes of Health Antiarrhythmics versus Implantable Defibrillator (AVID) study.
Unlike several other antiarrhythmics (eg, amiodarone), it has no pharmacokinetic drug-drug interactions, is not metabolized, and is entirely renally excreted. However, this case patient was not taking any other cardiac medication that could affect rhythm or contractility. The daily dose must be reduced in renal failure. Store sotalol away from heat, moisture and direct sunlight.
These cardiac changes reduce myocardial oxygen consumption and cardiac work. Patient only took one dose of sotalol 80 mg, before he developed cardiogenic shock with a prolonged QTc of 510 ms that was unresponsive to fluid resuscitation and high dose catecholamines vasopressors.
incompatibilités
Sotalol was withdrawn for a second time, and the vestibular symptoms again resolved.A 79-year-old woman with atrial fibrillation and hypertension, for which she had been taking sotalol 40 mg bd for 4 months, had a QTA 63-year-old woman with a non-ischemic dilated cardiomyopathy possibly caused by alcohol had paroxysmal atrial fibrillation for which she took sotalol 80 mg bd.
Elsevier Science