By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Patient risk factors included older age (odds ratios = 6.3) and concomitant use of (thiazide) diuretics (odds ratios = 11.2–13.5).Hyponatremia is a potentially dangerous side effect of antidepressants and is not exclusive to SSRIs. We defined hyponatremia as a sodium level ≤134 mEq/L, and severe hyponatremia as ≤128 mEq/L, in line with previous studies. Hyponatremia is a potentially dangerous side effect of antidepressants and is not exclusive to SSRIs. Unable to load your collection due to an error Current evidence suggests a relatively higher risk of hyponatremia with SSRIs and venlafaxine, especially when combined with patient risk factors, warranting clinicians to be aware of this complication. Although based on less solid evidence, incidence figures for mirtazapine and tricyclic antidepressants were lower. Treatment of isovolemia hypotonic hyponatremia associated with SSRI use includes water restriction and mild diuresis with a loop diuretic. 2018 Aug;35(8):763-772. doi: 10.1007/s40266-018-0570-2.Int J Environ Res Public Health.
Antidepressant-induced hyponatremia can cause significant morbidity and mortality. Regarding classes, odds ratios for SSRIs (1.5–21.6) were consistently higher than for tricyclic antidepressants (TCAs) (1.1–4.9). Epub 2019 Oct 11.Puga AM, Lopez-Oliva S, Trives C, Partearroyo T, Varela-Moreiras G.Nutrients. CONCLUSION: These results indicate that, among patients with MDD, SSRIs treatment may be associated with decreased serum sodium levels, and the elderly patients are at greater risk for hyponatremia. The risk of developing hyponatremia while on an SSRI was greater in elderly subjects (60 years and older). There have been few reports of rechallenge with the same or another SSRI or substitution of another agent from a different therapeutic class. Name must be less than 100 characters
2018 Jul 18;15(7):1515. doi: 10.3390/ijerph15071515. In the classic study by Fabian et al, 1 paroxetine, a selective serotonin reuptake inhibitors (SSRI), was found to induce hyponatremia in 12% of elderly patients within a mean duration of 9 days. Atypon It is well known that antidepressants can cause hyponatremia, particularly in elderly patients. Current evidence suggests a relatively higher risk of hyponatremia with SSRIs and venlafaxine, especially when combined with patient risk factors, warranting clinicians to be aware of this complication. Management. The risks associated with monoamine oxidase inhibitors, reboxetine, and bupropion could not be established owing to insufficient information.
Scenario: Management; Background information. 50 Some authors recommend a routine serum sodium analysis within the first 2 weeks after initiating such treatment in patients with additional risk factors for hyponatremia… In some, but not all, cases hyponatremia … Hyponatraemia is defined as a serum sodium concentration of less than 135 mmol/L. Definition; Pathophysiology; Causes; Incidence and prevelance; Risk factors; Complications; Hyponatraemia: Summary . 2005 Jul-Aug;39(7-8):1296-301. doi: 10.1345/aph.1E069. The risks associated with mirtazapine are moderate, supporting … 2004 Feb 9;164(3):327-32. doi: 10.1001/archinte.164.3.327.Ann Pharmacother. The risks associated with mirtazapine are moderate, supporting this antidepressant as an alternative treatment for patients with (an increased risk of) hyponatremia. Sodium levels should be checked in all elderly patients exhibiting abrupt or unexplained changes in mental status (e.g., lethargy or confusion) at any time during treatment with an SSRI or venlafaxine. Atypon ScienceDirect ® is a registered trademark of Elsevier B.V.Antidepressants and the Risk of Hyponatremia: A Class-by-Class Review of LiteratureCopyright © 2014 The Academy of Psychosomatic Medicine.
It is the most common electrolyte disorder encountered in clinical practice, and is usually an incidental … Conclusion: Hyponatremia is a potentially dangerous side effect of antidepressants and is not exclusive to SSRIs.
This complication can be serious, with delirium, seizure, or even death. 2020 Jan;52(1):57. doi: 10.1016/j.aprim.2019.05.009. The risks associated with mirtazapine are moderate, supporting this antidepressant as an alternative treatment for patients with (an increased risk of) hyponatremia.We use cookies to help provide and enhance our service and tailor content and ads. 5, 6 Potentially predictive variables for hyponatremia tested were the following: CBZ/OXC serum levels, age, sex, and concomitant AEDs. Because of variations in study designs, populations, and cutoff values, incidence rates diverged between 0.06% and 40% for SSRIs and 0.08% and 70% for venlafaxine.