Drug interactions with sertraline oral and clomipramine oral.
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Treatment effects persisted through 5 to 22 months of follow-up from onset of combination therapy.
Combination treatment with clomipramine and selective serotonin reuptake inhibitors for obsessive-compulsive disorder in children and adolescents. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed.
1999 Feb;60(2):101-6. doi: 10.4088/jcp.v60n0206.J Clin Psychiatry. 2013 Dec;74(12):e1128-33. 2006 Apr;3(2):192-206. doi: 10.1016/j.nurx.2006.01.009.Paediatr Drugs. The drug combination was effective in the 2 patients with OCD and no mood/anxiety comorbidity. Name must be less than 100 characters CMI could also potentially increase SSRI absorption and/or protein binding. Psychiatr Serv. It may increase the risk of suicide in those over the age of 20. Recommendations are made to monitor electrocardiograms, CMI blood concentrations, and vital signs in all cases because SSRIs can increase the blood levels of CMI and/or its active metabolite, desmethylclomipramine (DCMI). Always consult your doctor before taking these medications together. Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Author information: (1)Department of Psychiatry, University of … Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). Keys words:obsessive-compulsive disorder, sertraline, clomip- Sertraline dose-dependently slows the metabolism of clomipramine via CYP2D6.
Clomipramine pro-duced more side effects and dropout rate. Side effects appeared in 5 of 7 patients; cardiovascular side effects were the most common adverse effects.
Drug interactions are reported only by a few people who take Sertraline hydrochloride and Clomipramine hydrochloride together. Serious. The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.
The use of CMI and SSRI combination therapy was found to be more effective compared with their monotherapy in all 7 cases.
This open-label case series presents 7 patients (6 male, 1 female) ages 9 to 23 years with OCD who were effectively treated with combination of CMI plus an SSRI. 18.Preskorn SH, Alderman J, Chung M, Harrison W, Messig M, Harris S. Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine.
Unable to load your delegates due to an error The information provided here is for informational purposes only. Two patients had prolongation of QTc intervals and 2 developed tachycardia while taking CMI and SSRI combinations. sertraline oral and clomipramine oral both increase serotonin levels. Clipboard, Search History, and several other advanced features are temporarily unavailable. Interaction between Clomipramine and Zoloft: There is a moderate interaction between Clomipramine and Zoloft. Figueroa Y(1), Rosenberg DR, Birmaher B, Keshavan MS.
Clomipramine oral capsule is a prescription medication used to treat the excessive and repetitive ideas, thoughts, and impulses of obsessive-compulsive disorder. Please enable it to take advantage of the complete set of features!
The results indicate that sertraline is as effective as clomipramine in the treatment of OCD and is better tolerated. Potential for serious interaction; regular monitoring by your doctor required Frequently, OCD patients receiving monotherapy experience low treatment response rates and problematic side effects that may result in discontinuation or noncompliance. COVID-19 is an emerging, rapidly evolving situation. 1999 Sep;156(9):1409-16. doi: 10.1176/ajp.156.9.1409.J Psychiatr Pract.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Medication management of obsessive-compulsive disorder (OCD) has consisted of monotherapy with either clomipramine (CMI) or selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine, paroxetine, or sertraline. doi: 10.4088/JCP.13f08883.Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L.Am J Psychiatry.
Nevertheless, mistakes and omissions cannot be entirely excluded. 2003;5(9):583-95. doi: 10.2165/00148581-200305090-00002. … Too much serotonin is a potentially life-threatening situation.