Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It includes a chart (reproduced below) of drugs encountered up to the year 2000 and their dialysis status by type. Allergic reaction to castor oil HCO-60. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. *Please select more than one item to compare
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The product can be stored for up to 12 months.O[C@@H]1CC[C@H](C[C@H]1OC)C=C(/C)[C@H]2OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@]3(O)O[C@H]([C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]3C)OCFunctional Studies - FK506 (Tacrolimus), Immunosuppressant (ab120223)Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury.Extracellular calcium modulates brown adipocyte differentiation and identity.Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition.An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. You must have JavaScript enabled to use this form. Compare Products: Select up to 4 products. To our knowledge, customised protocols are not required for this product. Complexes with FKBP-12 to inhibit calcineurin.Store at -20°C. It is known that FK506 (Tacrolimus) is soluble to around 100 mM in ethanol.
Thus, isolated segments of rat jejunum, ileum, or colon were perfused with tacrolimus solutions containing polyethoxylated hydrogenated castor oil 60 surfactant, and with or without verapamil, a P‐gp substrate used to reverse the MDR phenotype.
Immunosuppressant. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C.
Tacrolimus According to Regulation (EC) No 1907/2006, Annex II, as amended. Curr Opin Investig Drugs.
Tacrolimus has an empirical formula of C 44 H 69 NO 12 •H 2 O and a formula weight of 822.03. Abcam community
Because of poor solubility in water, the conventional intravenous dosage forms of tacrolimus contain surfactants such as cremophor EL (BASF Wyandotte Co.) or hydrogenated polyoxy 60 castor oil (HCO-60) which may cause adverse effects. You can also search for this author in
GIT Anatomy and Physiology and Drug Oral Bioavailability: Impact of Species Differences, Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method, Comparison of X‐ray Powder Diffraction and Solid‐State Nuclear Magnetic Resonance in Estimating Crystalline Fraction of Tacrolimus in Sustained‐Release Amorphous Solid Dispersion and Development of Discriminating Dissolution Method, Chemometric Methods for the Quantification of Crystalline Tacrolimus in Solid Dispersion by Powder X‐Ray Diffractrometry, Near‐Infrared and Fourier Transform Infrared Chemometric Methods for the Quantification of Crystalline Tacrolimus from Sustained‐Release Amorphous Solid Dispersion, In vitro experimental system for evaluating inhibitory effect of investigational drugs on P‐glycoprotein‐mediated transcellular transport of tacrolimus (FK506), Advances in Therapeutic Development for Radiation Cystitis, Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans, Intravesical immune suppression by liposomal tacrolimus in cyclophosphamide‐induced inflammatory cystitis, Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations, Use of plasma proteins as solubilizing agents in in vitro permeability experiments: Correction for unbound drug concentration using the reciprocal permeability approach, Impact of cremophor‐EL and polysorbate‐80 on digoxin permeability across rat jejunum: Delineation of thermodynamic and transporter related events using the reciprocal permeability approach, Permeability assessment of poorly water‐soluble compounds under solubilizing conditions: The reciprocal permeability approach, Factors influencing regional differences in intestinal absorption of UK‐343,664 in rat: Possible role in dose‐dependent pharmacokinetics, Protein expression pattern of P–glycoprotein along the gastrointestinal tract of the yucatan micropig, Immunosuppressive Agents for the Prevention of Transplantation Rejection, Limited influence of P‐glycoprotein on small‐intestinal absorption of cilostazol, a high absorptive permeability drug, Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms,