D, Crowther L, Woosley Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin. H, Skates et al.
T, Martinez Interaction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized study. WP. Supratherapeutic International Normalized Ratios in Warfarin-Treated Patients Who Receive a Highly Potentiating Antimicrobial CourseLisa M. Daniels, MD; Jason N. Barreto, PharmD; Pritish K. Tosh, MDSupratherapeutic International Normalized Ratios in Warfarin-Treated Patients Who Receive a Highly Potentiating Antimicrobial Course—ReplyCatherine S. Riggs, PharmD; Thomas Delate, PhD; Nathan P. Clark, PharmDSupratherapeutic International Normalized Ratios in Warfarin-Treated Patients Who Receive a Highly Potentiating Antimicrobial CourseLisa M. Daniels, MD; Jason N. Barreto, PharmD; Pritish K. Tosh, MDSupratherapeutic International Normalized Ratios in Warfarin-Treated Patients Who Receive a Highly Potentiating Antimicrobial Course—ReplyCatherine S. Riggs, PharmD; Thomas Delate, PhD; Nathan P. Clark, PharmD W, Gallus L, Yusuf Data Collection Studies are needed to determine whether less-frequent INR monitoring can be safely used during coadministration of antibiotics less likely to interact with warfarin therapy.Figure. Monitor INR and increase dose accordingly. Study Outcomes sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto download free article PDFs, sign up for alerts, customize your interests, and moreto make a comment, download free article PDFs, sign up for alerts and more
SE, Hennessy Not every INR in the preindex period was between 2.0 and 3.5. Ageno Systematic overview of warfarin and its drug and food interactions. MA, Garcia S. Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleeding. T, Martinez D,
Acetaminophen and other risk factors for excessive warfarin anticoagulation. The mechanism appears to be via stimulation of the immune system, resulting in secretion of proinflammatory cytokines, such as tumor necrosis factor and interleukin. Effect of a centralized clinical pharmacy anticoagulation service on the outcomes of anticoagulation therapy. K. Empiric warfarin dose adjustment with prednisone therapy: a randomized, controlled trial. Mlinaric-Galinovic MA, Shanahan
Manufacturer advises use with caution or avoid.
Our website uses cookies to enhance your experience. In some cases, out-of-range preindex INRs may have produced warfarin dosage changes increasing INR variability during follow-up. CA, Fay
The risk of excessive anticoagulation for individual antibiotics varied according to the interaction mechanism with the greatest risk presented by antibiotics interfering with warfarin metabolism.
EM, Heiman A, K. Empiric warfarin dose adjustment with prednisone therapy: a randomized, controlled trial.
Tetracyclines increase INR by an unknown mechanism, potentially inhibiting warfarin metabolism and plasma prothrombin activity. American Heart Association/American College of Cardiology Foundation guide to warfarin therapy. V, Ansell
MB, Vavra RK. H, Bilker The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. EE. RL. Interaction mechanism was determined by cross-referencing 2 widely used drug interaction references.Continuous data were expressed as a mean (SD) or median with interquartile range and were compared using parametric or nonparametric analysis of variance as appropriate.
only be achieved by a 30-60% increase in warfarin dose.