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Aciclovir is not licensed for use in pregnancy but is not known to be harmful and should be first-line treatment. Women with active herpetic lesions near or on the breast should avoid nursing; topical use to small areas of the mother's body away from the breast should pose no risk to the infant. There are no controlled data in human pregnancy.Systemic exposure following oral administration is low suggesting topical use may be insignificant. Prober CG. 2001. Yes, acyclovir is considered to be absolutely safe and it can be taken during pregnancy. For Child 12–17 years.
This drug has not been studied prospectively in large numbers of pregnant women and lacks the Food and Drug Administration's approval for gestational use unless benefits clearly outweigh potential fetal harm. Thus, most often, this medicine is prescribed only in the later stages of … A total of 18 birth defects were reported with first trimester exposure (17 expected) and included (observed/expected) 5/4 cardiovascular defects, 1 polydactyly, and limb reductions (Written communication, Franz Rosa, MD, Food and Drug Administration, 1994). Aciclovir (ACV), also known as acyclovir, is an antiviral medication. Teratogenicity was not seen when administered to animal models throughout the period of major organogenesis. 400 mg twice daily, alternatively 200 mg 4 times a day; increased to 400 mg 3 times a day, dose may be increased if recurrences occur on standard suppressive therapy or for suppression of genital herpes during late pregnancy (from 36 weeks gestation), therapy interrupted every 6–12 months to reassess recurrence frequency—consider … Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. August 25, 2010;304(8):859–866. However, given the small size of the registry, the data is not sufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of this drug during pregnancy. AU TGA pregnancy category: B3 US FDA pregnancy category: B Comments: -This drug has been safely used to treat genital herpes in women in all stages of pregnancy.-Women who acquire genital herpes simplex virus (HSV) during late pregnancy should be managed in consultation with maternal-fetal medicine and infectious-disease specialists. This drug was not teratogenic in mouse, rabbit, or rat at exposures greatly more than human exposure. In addition to this, it may even cause congenital disabilities in the baby. Adverse effects in breast-feeding infants associated with exposure to this drug via breast milk have not been reported in the literature.
2010. However, if acyclovir is taken during the first trimester of pregnancy, it may lead to certain complications in the pregnancy. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Available for Android and iOS devices. Benefit should outweigh risk AU TGA pregnancy category: B3 US FDA pregnancy category: B. JAMA 304(8):859-866. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. Is it safe to use aciclovir in pregnancy? Animal studies have shown this drug readily crosses the placenta.
Pharmacokinetics of oral valacyclovir and acyclovir in late pregnancy. There is no evidence of an increased incidence of birth defects with either aciclovir or … By mouth. Pasternak B, Hviid A.