(Effect of antihistamines on H1R gene expression in HeLa cells. - Researchers conducted the study for comparing the efficacy, safety, and tolerability of bilastine, a novel H1 antihistamine, 20 mg vs levocetirizine 5 mg in moderate‐to‐severe chronic spontaneous urticaria (CSU).

Data are expressed as means ± SEM ( 0000030135 00000 n

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2010;65:516–528. Epub 2009 May 4.Int J Dermatol.

Chronic spontaneous urticaria (CSU) is a debilitating condition, adversely affecting the patient's quality of life. Safety was assessed by recording drug‐related adverse events, biochemical investigations, and electrocardiogram, along with tolerability and compliance.
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0000008744 00000 n Chronic spontaneous urticaria (CSU) is a debilitating condition, adversely affecting the patient's quality of life. Affiliations

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trailer doi: 10.1097/MD.0000000000017115.Thomas J, Saple DG, Jerajani HR, Netha NRG, Rangasamy DU, Shaikh R, Babu RP, Powar I, Mhatre S, Vase S, Srisha MM, Mehta S, Mittal R, Acharya S, Charugulla SN.Dermatol Ther (Heidelb).

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We wanted to compare the effectiveness, safety, and tolerability of bilastine 20 mg vs levocetirizine 5 mg in moderate‐to‐severe CSU.

It was developed in Spain by FAES Farma.



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2009 Aug;31(8):1664-87. doi: 10.1016/j.clinthera.2009.08.015.Drugs.

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0000045863 00000 n 2019 Jun;9(2):299-308. doi: 10.1007/s13555-019-0293-2. In addition, urticaria-associated discomfort (p < 0.001 for change from day 0 to day 28, and p < 0.001 for bilastine/levocetirizine vs placebo) and sleep disturbance (p < 0.001 for bilastine/levocetirizine vs placebo, using Chi square test) were significantly reduced after bilastine or levocetirizine treatment compared to placebo . 0000041570 00000 n

2006 Apr;45(4):469-74. doi: 10.1111/j.1365-4632.2005.02609.x.Nettis E, Colanardi MC, Barra L, Ferrannini A, Vacca A, Tursi A.Br J Dermatol.



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Collaborators, Epub 2019 Jun 11.Kitamura Y, Nakagawa H, Fujii T, Sakoda T, Enomoto T, Mizuguchi H, Fukui H, Takeda N.J Pharmacol Sci. 0000044288 00000 n 0000042682 00000 n 0000002655 00000 n Multidisciplinary Digital Publishing Institute (MDPI)

(Effect of rupatadine and desloratadine on H1R gene expression in HeLa cells. 2016 Jan;15(1):89-98. doi: 10.1517/14740338.2016.1112786. Both drugs significantly improved UAS7, DLQI, and VAS at end‐of‐treatment (D42) compared with baseline (intra‐group). Bilastine is a recently introduced, non‐sedative H1‐antihistamine for its treatment. 0000007470 00000 n 0000030580 00000 n Wiley

2009 Sep;39(9):1338-47. doi: 10.1111/j.1365-2222.2009.03257.x.

Epub 2013 Feb 20.J Pharmacol Sci. Bilastine, sold under the brand name BILLASI among others, is a second-generation antihistamine medication which is used in the treatment of allergic rhinoconjunctivitis and urticaria (hives)..

2019 Sep;98(38):e17115.

xref 2012 Jun 18;72(9):1257-69. doi: 10.2165/11209310-000000000-00000.Sádaba B, Azanza JR, García-Bea A, Labeaga L, Campo C, Valiente R.Eur J Drug Metab Pharmacokinet. Unable to load your delegates due to an error

It exerts its effect as a selective histamine H 1 receptor antagonist, and has an effectiveness similar to cetirizine, fexofenadine, and desloratadine.

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2006 Mar;154(3):533-8. doi: 10.1111/j.1365-2133.2005.07049.x.Singh-Franco D, Ghin HL, Robles GI, Borja-Hart N, Perez A.Clin Ther. ( Effect of antihistamines on H1R gene expression in HeLa cells.

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