This information is intended for use by health professionalsEach gram of gel contains 10 mg (1%) clindamycin (as clindamycin phosphate) and 0.25 mg (0.025%) tretinoin.Treclin is indicated for the topical treatment of acne vulgaris when comedones, papules and pustules are present in patients 12 years or older (see section 4.4 and 5.1) Consideration should be given to official guidance on the appropriate use of antibacterial agents and acne treatment.Once daily at bedtime the entire face should be washed with mild soap and dried.
damaged skin barrier, excessive use) that contribute to an increased systemic exposure.It is not known whether tretinoin and clindamycin are secreted in breast milk following the use of Treclin. This is unlikely to occur with Treclin as plasma levels have been determined and the percutaneous absorption of clindamycin is clinically negligible.If you notice prolonged diarrhea or suffer from abdominal cramps, treatment with Treclin should be discontinued immediately as the symptoms may indicate antibiotic-associated colitis. The incidence of dry skin in adolescent population (12-17 years) was slightly higher in clinical trials than in the overall population.Reporting suspected adverse reactions after authorisation of the medicinal product is important. Neither single-dose nor long-term treatment with topical tretinoin formulations does alter systemic retinoid levels, which remain within the range of body's natural endogenous levels.
It severely affects fertility and peri-postnatal development. The combination of the two active ingredients are more effective when combined than if used separately.Non-prescription alternatives to Treclin gel include benzoyl peroxide gel, such as Acnecide. confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. Continue typing to refine. Ive aways suffered with my skin since i was about 16 years old. Tretinoin plasma concentrations were below the lower limit of quantitation (LLOQ; 1 ng/mL) in 50% to 92% of subjects at any given time point following administration and were near the LLOQ in the remaining subjects, with values ranging from 1.0 to 1.6 ng/mL. Superiority vs. monotherapies was concluded if two of three lesion count variables and dichotomized EGSS were significant.Treatment was applied once daily for 12 weeks and patients were evaluated and lesions counted at week 12. It helps to kill the bacteria that cause acne, however, it is not an antibiotic. Clindamycin was not teratogenic in reproduction studies in rats and mice, using subcutaneous and oral doses of clindamycin (see section 5.3)Orally administered retinoids have been associated with congenital abnormalities. There are no available data on fertility on Treclin.Reproduction studies in rats and mice, using subcutaneous and oral doses of clindamycin, revealed no evidence of impaired fertility.Systemically administered tretinoin severely affects fertility. If you do experience sunburn whilst using the treatment, you should stop using Treclin until this has fully healed.You should not use sunbeds or other UV lights whilst using Treclin. It is important to use the gel daily and to continue using Treclin when you start to see an improvement for the best effects.If you experience side effects such as redness or irritation in the area of application, you should stop using Treclin gel until the symptoms resolve. If sunburn occurs, discontinue therapy with Treclin until the severe erythema and peeling subside. {{{ result.pack_size }}} for {{{ result.condition }}}Order before 3pm for delivery from ▪ In patients who have a history of hypersensitivity to the active substances clindamycin and/or tretinoin or to any of the excipients or lincomycin (see also Section 6.1) The same adverse reactions effects as those expected with clindamycin (i.e.